KRYSTEXXA® Connexxions
Patient Support Program

If you're ready to take a stand against Refractory Chronic Gout (RCG), we're ready to help–with the KRYSTEXXA® Connexxions Patient Support Program.

The KRYSTEXXA® Connexxions Patient Support Program is a free program that provides you with a range of services and resources designed to make KRYSTEXXA treatment as simple and convenient as possible.

When you register for the KRYSTEXXA® Connexxions Patient Support Program, you will receive a free Welcome Kit and access to the following services:

Personal Support Specialists

Get live support from a Personal Support Specialist who will call you regularly to check in on how you're doing with your KRYSTEXXA treatment. In addition to being able to answer or refer your questions, your Personal Support Specialist can:

  • Help you understand what you may expect from KRYSTEXXA treatment
  • Track your treatment progress
  • Remind you of infusion appointments
  • Remind you about scheduling your blood tests

Other available assistance

Patient Assistance Program
If you don't have insurance and need help with the cost of KRYSTEXXA, please ask your doctor's office to call the KRYSTEXXA® Connexxions hotline for more information.

Co-Pay Assistance Program
If you have commercial health insurance and would like to inquire about co-pay assistance, please ask your doctor's office to call the KRYSTEXXA® Connexxions hotline for more information.

Important Safety Information

Before starting KRYSTEXXA® (pegloticase), you should know that:

KRYSTEXXA is for adults who have tried or can not take oral gout medicines and still have high uric acid levels and gout signs and symptoms, also known as Refractory Chronic Gout.

KRYSTEXXA is not recommended if you have high levels of uric acid without signs and symptoms of gout.

You should not use KRYSTEXXA if you have a genetic condition known as G6PD deficiency, which stands for glucose-6-phosphate dehydrogenase deficiency. This is also known as favism. G6PD deficiency occurs more often in people of African or Mediterranean family background. However, it can occur in anyone. Before giving you KRYSTEXXA, your doctor may give you a blood test to determine if you have G6PD deficiency.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Have, or ever had, heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk. You and your doctor should decide if you will receive KRYSTEXXA or breastfeed

What is the most important information I should know about KRYSTEXXA?

Serious allergic reactions may happen in some people who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

There are possible side effects with KRYSTEXXA:

The most common serious side effects in patients taking KRYSTEXXA were severe allergic reactions and infusion reactions. The most common side effects were gout flare-ups or attacks, infusion reactions, nausea, bruising, sore throat, constipation, chest pain, severe allergic reactions, and vomiting.

An increase in gout flares is frequently observed in patients when they start taking medicines to lower their uric acid levels. Patients do not need to stop taking KRYSTEXXA simply because of gout flares.

This is not a complete list of all possible side effects. Ask your doctor or treatment team if you have any questions or want more information.

If you have any questions about KRYSTEXXA or your therapy, talk with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.

Please see the Medication Guide and Prescribing Information, including Boxed Warning, for more information.

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