About Chronic Gout

Even When You Aren’t Having a Flare, You Still Have Gout

Gout is the most common form of inflammatory arthritis, affecting 8.3 million Americans. Like other types of arthritis, gout is an ongoing disease that can get worse without the right treatment.

You probably know that your gout is caused by too much uric acid in your system. High levels of uric acid can build up and form crystals in your joints and throughout your body. As the crystals accumulate, they can form clumps called tophi that may damage the bone. At this point, patients can find it difficult to move without experiencing pain.

In Patients With Gout
Too Much Uric Acid
Gout Crystals
Gout Signs & Symptoms

Gout crystals are not always visible and can remain in your body after a gout flare ends. Even when you have no symptoms, crystals can continue to accumulate, leading to:

  • More frequent and painful gout flares
  • Lumps of uric acid crystals under the skin, called tophi
  • Bone and joint damage

Patients with chronic gout may have ongoing symptoms that are difficult to control. Usually it’s because they cannot maintain a uric acid level less than 6 mg/dL. Above this level, crystals, or tophi, can accumulate. If you’ve tried standard doses of oral gout medications and you still have symptoms, your gout may be “uncontrolled.”

  • FOUR OUT OF 10

    people with gout believe they can stop taking medications in the absence of a flare

    THE TRUTH IS

    even when you’re not having symptoms, if your uric acid level is not controlled, gout crystals can continue to build up in your body.
  • APPROXIMATELY HALF

    of the patients taking standard oral uric acid lowering treatments, such as allopurinol and febuxostat, do not keep their uric acid level low enough to dissolve gout crystal buildup

    THE TRUTH IS

    gout can be difficult to control. That’s why adding a specialist to your care team can often make a difference.
  • HALF OF GOUT SUFFERERS

    do not know gout can lead to serious bone, joint, or tissue damage

    THE TRUTH IS

    without the right gout treatment, symptoms can get worse over time.
  • HALF OF GOUT PATIENTS

    incorrectly believe it is a disease that “comes and goes”

    THE TRUTH IS

    even when you don’t have symptoms, gout is there.
  • JUST 1 IN 4

    patients checked their uric acid levels in the past 6 months

    THE TRUTH IS

    over time, high uric acid levels can cause crystals (called tophi) to form under the skin. It is important to keep track of your uric acid levels.
  • 6 IN 10 AMERICANS

    don’t know that elevated uric acid increases risk for gout

    THE TRUTH IS

    the leading risk factor for gout is a buildup of uric acid in the bloodstream.
DID YOU KNOW?*

Watch Gary’s Story

Gary was only 24 when he was diagnosed with gout. A few years ago, his gout symptoms were uncontrolled, despite having tried several medications. Finally, he met with a gout specialist and learned about KRYSTEXXA.

Target Symptom Improvement

Keeping your gout under control can be very difficult

Even with standard oral treatments such as allopurinol or febuxostat, lowering your uric acid can be challenging.

  • Approximately half of patients taking a standard oral gout treatment are still unable to reach a uric acid level of 6 mg/dL or lower

Researchers found that a crystal deposit the size of a small marble could take more than 2 years to dissolve, even with a uric acid level of 6 mg/dL

One study has shown that the lower your uric acid level, the faster tophi are reduced.

  • For patients with chronic gout, treatment goal is to achieve a uric acid level of 6 mg/dL or below
  • For patients who have recurring symptoms, including those with visible lumps of uric acid (tophi), uric acid level should often be lowered to 5 mg/dL or below

*Source: Gout & Uric Acid Education Society
A European study.
According to American College of Rheumatology (ACR) guidelines.

Selected Important Safety Information

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

Find a Gout Specialist
Find a Gout Specialist

Gout specialists, usually rheumatologists, have expertise in treating joint diseases like gout. They may have access to a broader range of gout treatments that could help you. Enter your zip code below to find a specialist for the treatment of your gout.

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Get Customized Help for Your Gout
Get Customized Help for Your Gout

Sign up for customized information that includes helpful tips for living with gout, as well as resources for your next doctor’s appointment. Plus, you can learn from other gout patients as they share their experience and how KRYSTEXXA helped them.

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USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please see the Medication Guide and Prescribing Information for more information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-10881-800-FDA-1088.

USE and IMPORTANT SAFETY INFORMATION

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

Please see the Medication Guide and Prescribing Information for more information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-10881-800-FDA-1088.