About KRYSTEXXA®

KRYSTEXXA: Learn about a different way to treat chronic gout

KRYSTEXXA is the only FDA-approved prescription medicine for adults who have tried other gout medicines (or cannot take them) and who still have high uric acid and gout signs and symptoms.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

KRYSTEXXA works differently than other medications you may have tried for your gout

KRYSTEXXA is an enzyme that changes uric acid into allantoin. Allantoin is a water-soluble substance that can be easily removed by the body.

Proven results with KRYSTEXXA

KRYSTEXXA was studied in two 6-month clinical trials in 85 adult patients diagnosed with chronic gout. Patients in the studies received either KRYSTEXXA (8 mg dose) or placebo every two weeks.

42% of patients on KRYSTEXXA kept their uric acid level below 6 mg/dL over a 6-month period*

45% of patients who received KRYSTEXXA every 2 weeks for 6 months saw at least 1 tophi disappear*

Individual cases and results may vary.

*In clinical studies, patients receiving KRYSTEXXA who kept their uric acid level below target (<6 mg/dL) had an average uric acid level of less than 1 mg/dL. Patients receiving a placebo had an average uric acid level of 8.6 mg/dL during the studies. Your doctor may stop your KRYSTEXXA if your uric acid levels do not become normal and stay controlled or you have certain side effects.

Selected Important Safety Information
KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Dosing and Administration for KRYSTEXXA

Krystexxa is an IV (intravenous) infusion given every 2 weeks. The infusion time for KRYSTEXXA takes about 2 hours or sometimes longer. Your doctor will want you to come prior to your infusion for pre-medication and stay after for monitoring, so you should plan for approximately 3-4 hours for your KRYSTEXXA treatment.

In clinical trials, KRYSTEXXA was given for up to 6 months, however your length of therapy will be based on your treatment goals. You and your rheumatologist will decide when therapy should be stopped.

  • The decision to stop is based on a few factors, including how you respond to treatment and whether KRYSTEXXA helps control your uric acid level
  • Your rheumatologist will monitor your uric acid level during treatment. If your uric acid level gets too high, it means KRYSTEXXA may no longer work for you

What are the possible side effects of taking KRYSTEXXA?

Like other medicines that work to lower uric acid, when receiving KRYSTEXXA, over the first 3 months, you may have an increase in gout flares. This may happen due to the crystals in your joints beginning to dissolve.

You should not stop KRYSTEXXA treatment if you have a flare. Your doctor may prescribe other medicines to help reduce the chance of gout flares.

Other common side effects included:

  • Severe allergic reactions
  • Infusion reactions
  • Nausea
  • Bruising
  • Sore throat
  • Constipation
  • Chest pain
  • Vomiting

Who shouldn’t receive KRYSTEXXA?

KRYSTEXXA may not be right for everyone. KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

You should not use KRYSTEXXA If you have a genetic condition known as glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency), also known as favism. While G6PD deficiency may occur in anyone, it occurs more often in those of African or Mediterranean descent.

Before prescribing KRYSTEXXA your doctor should give you a blood test to determine if you have G6PD deficiency.