KRYSTEXXA Treatment

KRYSTEXXA is Given Differently Because it Works Differently

KRYSTEXXA is given as an intravenous (IV) infusion

  • You’ll be given KRYSTEXXA at your doctor’s office or treatment center so that you can be monitored during your treatment

You’ll receive KRYSTEXXA every 2 weeks

  • Your treatment will be administered and monitored by a doctor or nurse
  • The infusion time for KRYSTEXXA takes 2 hours or sometimes longer

The treatment process may take up to 4 hours

  • Your doctor will want you to come prior to your infusion for pre-medication and stay after for monitoring, so you should plan on approximately 3-4 hours for your treatment
  • If you experience any side effects during your treatment, your doctor may stop or slow the infusion or give you medication to treat the side effects

Length of Treatment

How long you receive KRYSTEXXA will be based on how you respond to treatment. In clinical studies, KRYSTEXXA was given every 2 weeks for up to 6 months. You and your gout specialist will decide when therapy should be stopped.

  • The decision to stop is based on a few factors, including how you respond to treatment and whether KRYSTEXXA helps control your uric acid level.
  • Your gout specialist will monitor your uric acid level during treatment. If your uric acid level gets too high, it means KRYSTEXXA may no longer work for you.

Infusion Day: Treating Gout

Jen’s Treatment with KRYSTEXXA

Jen coped with gout symptoms for several years. When oral gout medications did not bring relief, her rheumatologist told her about KRYSTEXXA. Watch this video that takes you through Jen’s infusion experience, along with her doctor and nurse, to learn what to expect during your treatment.

Treatment Considerations

  • If your uric acid levels do not reach a normal level, stay controlled, or if you have certain side effects, your doctor may discontinue the use of KRYSTEXXA.
  • KRYSTEXXA treatment may actually cause flares for the first 3 months. In fact, all medicines that lower uric acid may cause gout flares when they’re first taken. This is usually a sign that the medication is taking effect as the crystals in your joints begin to dissolve. The flares usually subside after the first few months of treatment.
  • You should not stop your treatment if you do have a gout flare. During treatment, your doctor may prescribe other medicines to help reduce the chance of gout flares.
  • Prior to your treatment with KRYSTEXXA your doctor may give you medicine to reduce your chance of getting an allergic reaction. Take these medicines as directed by your doctor or nurse.

Other KRYSTEXXA side effects may include:

  • Severe allergic reactions
  • Infusion reactions
  • Nausea
  • Bruising
  • Sore throat
  • Constipation
  • Chest pain
  • Vomiting

This is not a complete list of all possible KRYSTEXXA side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Who Shouldn’t Receive KRYSTEXXA?

KRYSTEXXA may not be right for everyone. KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

You should not use KRYSTEXXA if you have a genetic condition known as glucose 6-phosphate dehydrogenase deficiency (G6PD deficiency), also known as favism. While G6PD deficiency may occur in anyone, it occurs more often in those of African or Mediterranean descent.

Before prescribing KRYSTEXXA your doctor should give you a blood test to determine if you have G6PD deficiency.

Selected Important Safety Information

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

Find a Gout Specialist
Find a Gout Specialist

Gout specialists, usually rheumatologists, have expertise in treating joint diseases like gout. They may have access to a broader range of gout treatments that could help you. Enter your zip code below to find a specialist for the treatment of your gout.

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USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please see the Medication Guide and Prescribing Information for more information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-10881-800-FDA-1088.

USE and IMPORTANT SAFETY INFORMATION

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

Please see the Medication Guide and Prescribing Information for more information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-10881-800-FDA-1088.