Why KRYSTEXXA

A Different Way to Get Gout Out

KRYSTEXXA works differently to treat gout. Most gout medications target uric acid levels by affecting the production or removal of uric acid from the body.

KRYSTEXXA changes uric acid to a substance your body can easily get rid of through urine:

  • KRYSTEXXA rapidly lowers uric acid levels. Within 24 hours the average uric acid level of patients receiving KRYSTEXXA was 1mg/dL*
  • By lowering uric acid levels, KRYSTEXXA helps dissolve the buildup of uric acid crystals from your body

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

*This result is from the studies described below.

KRYSTEXXA works to reduce uric acid levels and helps dissolve buildup of uric acid crystals from your system

This is a visual simplification of how KRYSTEXXA works. Results may vary.

Watch Jen’s Story

Jen’s gout symptoms were so severe, especially in her foot, that she described the feeling as “bone crushing.” She had tried different medications, but nothing helped her symptoms. Finally, she met with a gout specialist, who told her about KRYSTEXXA.

KRYSTEXXA: A Treatment for Chronic Gout

KRYSTEXXA works to reduce uric acid and to help dissolve and remove crystal buildup in patients with uncontrolled gout symptoms. It was studied in gout patients who had high uric acid levels and suffered from gout symptoms and flares despite being on daily treatment.

KRYSTEXXA can help keep uric acid levels low

  • 42% of patients receiving KRYSTEXXA kept their uric acid level below 6 mg/dL for 6 months or more
  • The rest of the patients in the clinical trials were able to keep their uric acid level below the goal of 6 mg/dL for an average of 7 weeks

KRYSTEXXA can help remove the buildup of uric acid crystals

  • 45% of patients on KRYSTEXXA had one visible tophi (uric acid buildup) go away completely in 6 months. These patients also did not have any growth of current tophi or new tophi

Results with KRYSTEXXA after 6 months

Actual patient cases treated with KRYSTEXXA. Individual results may vary.

KRYSTEXXA was studied in two 6-month clinical trials in 85 adult patients diagnosed with chronic gout. Patients in the studies received either KRYSTEXXA (8 mg dose) or placebo every 2 weeks. Most patients continued to receive KRYSTEXXA in a follow-on study.

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor may test you for G6PD before you start KRYSTEXXA.

Selected Important Safety Information

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

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Find a Gout Specialist

Gout specialists, usually rheumatologists, have expertise in treating joint diseases like gout. They may have access to a broader range of gout treatments that could help you. Enter your zip code below to find a specialist for the treatment of your gout.

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USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please see the Medication Guide and Prescribing Information for more information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-10881-800-FDA-1088.

USE and IMPORTANT SAFETY INFORMATION

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

Please see the Medication Guide and Prescribing Information for more information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-10881-800-FDA-1088.