See how KRYSTEXXA® works for these people with Refractory Chronic Gout

(RCG)

KRYSTEXXA has helped some people whose uric acid levels and gout signs and symptoms were not controlled by standard gout medicines. And KRYSTEXXA is the first and only medicine that has been shown in studies to get rid of tophi within just 6 months' time.

Click on a person below to see their story.

Dave R.
Age:
53
Location:
Terre Haute, IN

RCG signs and symptoms: Frequent flare-ups, tophi, standard gout medicines don't work

Dave's Story

Because my signs and symptoms could not be controlled with standard gout medicines, my doctor said I have RCG. He told me about a medicine that may control it, called KRYSTEXXA. I've been taking KRYSTEXXA for about half a year now. Slowly but surely, my RCG is getting under control.

Mark B.
Age:
60
Location:
San Francisco, CA

RCG signs and symptoms: Frequent flare-ups, tophi, standard gout medicines don't work

Mark's Story

My doctor told me about a medicine for RCG called KRYSTEXXA that had helped some people get rid of their tophi. I've been taking KRYSTEXXA for around 6 months and the change has been remarkable for me! My tophi have stopped growing and one on my ring finger is completely gone. I can even wear my wedding ring again!

Wendy K.
Age:
55
Location:
Savannah, GA

RCG signs and symptoms: Flare-ups, gouty arthritis, allergic to standard gout medicines

Wendy's Story

Recently my doctor told me about KRYSTEXXA, a medicine for people like me who can't take other gout medicines because of side effects. I've been receiving KRYSTEXXA for a while now and my RCG is now under control.

Tommy S.
Age:
50
Location:
Bronx, NY

RCG signs and symptoms: Frequent flare-ups, tophi, standard gout medicines don't work

Tommy's Story

When my doctor told me that I have RCG, which stands for Refractory Chronic Gout, I had hope for the first time in a long time that something might work for me! He put me on KRYSTEXXA, the first and only medicine that treats gout that's not controlled by other gout medicines, and my tophi have actually begun to shrink and go away!

Not actual patients.
  • Before KRYSTEXXA See where these patients started
  • Learn about KRYSTEXXA<sup>®</sup>The only treatment approved for RCG
  • Talk to your doctor Steps to take if you think you have RCG
  • RCG patients generally have more than 3 flares per year






























Get important updates and information

Important Safety Information

Before starting KRYSTEXXA® (pegloticase), you should know that:

KRYSTEXXA is for adults who have tried or can not take oral gout medicines and still have high uric acid levels and gout signs and symptoms, also known as Refractory Chronic Gout.

KRYSTEXXA is not recommended if you have high levels of uric acid without signs and symptoms of gout.

You should not use KRYSTEXXA if you have a genetic condition known as G6PD deficiency, which stands for glucose-6-phosphate dehydrogenase deficiency. This is also known as favism. G6PD deficiency occurs more often in people of African or Mediterranean family background. However, it can occur in anyone. Before giving you KRYSTEXXA, your doctor may give you a blood test to determine if you have G6PD deficiency.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Have, or ever had, heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk. You and your doctor should decide if you will receive KRYSTEXXA or breastfeed

What is the most important information I should know about KRYSTEXXA?

Serious allergic reactions may happen in some people who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

There are possible side effects with KRYSTEXXA:

The most common serious side effects in patients taking KRYSTEXXA were severe allergic reactions and infusion reactions. The most common side effects were gout flare-ups or attacks, infusion reactions, nausea, bruising, sore throat, constipation, chest pain, severe allergic reactions, and vomiting.

An increase in gout flares is frequently observed in patients when they start taking medicines to lower their uric acid levels. Patients do not need to stop taking KRYSTEXXA simply because of gout flares.

This is not a complete list of all possible side effects. Ask your doctor or treatment team if you have any questions or want more information.

If you have any questions about KRYSTEXXA or your therapy, talk with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.

Please see the Medication Guide and Prescribing Information, including Boxed Warning, for more information.

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