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Explore each step of
the KRYSTEXXA treatment journey

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Step 1: Schedule your first blood test

To make sure KRYSTEXXA is right for you, your doctor or gout specialist will check your uric acid level and G6PD (glucose 6-phosphate dehydrogenase) enzyme.

Step 2: Confirm your insurance

This is a great time to get help from a Patient Access Liaison (PAL), who can explain your health coverage, help fill out any paperwork, and help make sure you get KRYSTEXXA for the lowest cost.

Step 3: Connect with a peer mentor

While you wait for your blood test results, talk with KRYSTEXXA patients who can answer your questions, share their treatment experience, and provide moral support.

Step 4: Choose your treatment location

You can get KRYSTEXXA in a variety of IV treatment settings. Learn about your options and decide which is best for you.

Step 5: Schedule a second blood test

Your doctor will recheck your uric acid level a day or two before your first infusion and every infusion that follows. Stop taking your oral gout medicine a week before your first IV treatment.

Step 6: Pick up any prescriptions

Your doctor may give you something to help prevent an allergic reaction.

Learn more about how KRYSTEXXA works with a medication called methotrexate.

Step 7: Receive your first IV treatment

Whether you go to an IV treatment center or doctor’s office, the process is similar:

  • Icon of checking in during IV gout treatmentCheck in
  • Icon of starting KRYSTEXXA infusion during IV gout treatmentStart IV treatment
  • Icon of time passing during IV gout treatmentWait about 2 hours for your treatment to finish
  • Icon of scheduling next IV treatmentSchedule your next IV treatment
  • Icon of ensuring readiness after IV gout treatmentCheck out
  • Icon of driving home after KRYSTEXXA infusion treatmentDrive yourself home

Repeat this process every 2 weeks until your doctor determines your treatment is complete. It’s important to stay on track and not miss an appointment. Learn about Jen’s treatment experience.

Learn more about how KRYSTEXXA works with a medication called methotrexate.

Step 8: Celebrate!

Your first IV treatment is a big milestone. In just 24 hours, KRYSTEXXA can get your uric acid level low enough to start dissolving years of gout buildup. Mobilization flares can be a sign KRYSTEXXA is working.

Step 9: Check in with your PAL

In addition to helping you get started with KRYSTEXXA, a Patient Access Liaison (PAL) can answer any questions that come up after your first treatment and help you prepare for the months ahead. How you connect with your PAL and how often you connect is completely up to you.

Step 10: Continue your treatment

After the first 3 months, you may start seeing improvements in your gout. Even if your symptoms start to go away, it’s important to stay on KRYSTEXXA for about 6 months or until your doctor stops treatment. Each dose of KRYSTEXXA may help keep your uric acid level in the dissolve zone to reduce uric acid crystal buildup and help you take control of gout.

Step 11: Make it to the finish line

Stay on track by scheduling your remaining IV treatments at the same time. Your doctor will monitor your progress and let you know when you’re done. Learn about Brian's treatment journey and how his dedication to therapy helped him find relief from out-of-control gout.

Step 12: Do something special

  • Icon of celebrating after final gout infusion treatmentCongratulations! Now that you’ve completed KRYSTEXXA and are in control of gout, do something special to celebrate, like signing up to become a peer mentor so you can help others.

If your doctor has prescribed a medication called methotrexate along with KRYSTEXXA, you’ll start methotrexate approximately 4 weeks before your first KRYSTEXXA infusion. You’ll continue taking methotrexate for the duration of your treatment. Learn more about how KRYSTEXXA works with a medication called methotrexate.

USE AND IMPORTANT SAFETY INFORMATION

KRYSTEXXA® (pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).

USE

KRYSTEXXA® (pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • dizziness, fainting, fast or weak heartbeat or feeling nervous
  • reddening of the face, itching, hives, or feeling warm
  • swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you:

  • have a rare blood problem called glucose-6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor may test you for G6PD before you start KRYSTEXXA.
  • have had a serious allergic reaction to KRYSTEXXA or any of its ingredients. See the end of the Medication Guide for a complete list of ingredients in KRYSTEXXA.

What should I tell my doctor before receiving treatment with KRYSTEXXA?

Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if you:

  • ever had any heart problems or high blood pressure.
  • are pregnant or plan to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk. You and your doctor should decide if you will receive KRYSTEXXA or breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.

KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

In KRYSTEXXA clinical trials:
The most common side effects of KRYSTEXXA when given together with methotrexate were
gout flares, joint pain, coronavirus disease 2019 (COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA were gout flares, allergic reactions (including infusion reactions). See “What is the most important information I should know about KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain, coronavirus disease 2019 (COVID-19), and vomiting.
This is not a complete list of all possible side effects. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call
1-800-FDA-1088.

For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.

USE AND IMPORTANT SAFETY INFORMATION

KRYSTEXXA® (pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).

USE

KRYSTEXXA® (pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • dizziness, fainting, fast or weak heartbeat or feeling nervous
  • reddening of the face, itching, hives, or feeling warm
  • swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you:

  • have a rare blood problem called glucose-6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor may test you for G6PD before you start KRYSTEXXA.
  • have had a serious allergic reaction to KRYSTEXXA or any of its ingredients. See the end of the Medication Guide for a complete list of ingredients in KRYSTEXXA.

What should I tell my doctor before receiving treatment with KRYSTEXXA?

Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if you:

  • ever had any heart problems or high blood pressure.
  • are pregnant or plan to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk. You and your doctor should decide if you will receive KRYSTEXXA or breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.

KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

In KRYSTEXXA clinical trials:
The most common side effects of KRYSTEXXA when given together with methotrexate were
gout flares, joint pain, coronavirus disease 2019 (COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA were gout flares, allergic reactions (including infusion reactions). See “What is the most important information I should know about KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain, coronavirus disease 2019 (COVID-19), and vomiting.
This is not a complete list of all possible side effects. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call
1-800-FDA-1088.

For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.