Tophi (TOE-f-EYE) are telltale signs your gout is out of control. When uric acid levels remain high, deposits of uric acid crystals can develop into hard visible lumps that damage your joints and bones. Tophi can be microscopic or large and, though rare, may need to be surgically removed. It’s also possible for tophi to erupt on their own.

KRYSTEXXA CAN MAKE A DRAMATIC DIFFERENCE TREATING TOPHI

In clinical trials, nearly half of KRYSTEXXA patients had at least one tophus completely go away after 6 months, and they didn’t experience any new tophi growth. Finishing all your treatments is important to get the full benefit of KRYSTEXXA.

  • Before
  • At 3 months
  • At 6 months

TOPHI CAN GROW FROM HEAD TO TOE

Tophi foot picture Tophi foot picture
Tophi near toe
Picture of tophi in elbows Picture of tophi in elbows

WATCH ED’S STORY

“I placed my arm on the counter to pay and the tophi burst.”

Read transcript

Ed:

My gout symptoms began in 1996, when I was 48 years old. I had pain in my big toe, and then my elbow. I had gone to see my primary care physician and she initially thought my pain was a bunion, but the pain came back and spread over the next few years. At that time, I was referred to an orthopedist who diagnosed me with pseudo-gout. I tried a variety of treatments, including Prednisone to manage my flares and Allopurinol to lower my uric acid levels.

Ed:

But overall nothing was really keeping my gout under control. When my gout was at it's very worse, I was getting attacks several times a month. Eventually I came to a turning point. I took my dog Belle to the vet, placed my arm upon the counter to pay and the tophi burst. It took 17 years for me to finally get to a rheumatologist. When my doctor realized that I was in need of a different solution and we had tried everything else, he mentioned KRYSTEXXA He told me it was designed to lower uric acid levels and that it was different than other treatments I had tried before.

Narrator:

KRYSTEXXA is a prescription medicine for adults who have tried other gout medicines and still have high uric acid and gout symptoms. KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout. Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within two hours of the infusion. Please listen to the important safety information in this video.

Dr. Gary Crump:

I'm Dr. Gary Crump, a rheumatologist. I've been treating patients with gout for over 30 years. As many of you may be finding out, gout is an ongoing or chronic disease that can get worse without the right treatment.

Dr. Gary Crump:

Everyone has some uric acid in their body. Uric acid is made from the natural breakdown of your body cells and from some of the foods you eat. The body is usually able to eliminate the substance, keeping uric acid levels below six milligrams per deciliter. People with gout are unable to rid the body of uric acid so it starts to accumulate or build up in the joints and some of the organs. Over time the uric acid forms crystals that clump together. These clumps called tophi settle in your joints, where they cause pain. Sometimes the tophi are visible and appear as lumps under the skin. They can show up almost anywhere, but are most common on feet, hands, ankles, elbows and even ears.

Dr. Gary Crump:

Uric acid can also accumulate in organs. For example, uric acid that crystallizes in the kidneys can become kidney stones, which can cause problems. Even without symptoms, gout can get worse. This is because the uric acid continues to build up. Over time, uncontrolled high levels of uric acid can cause more inflammation, more pain and more frequent flares. When this happens, you may have chronic uncontrolled gout. If your gout is not adequately treated, it can lead to permanent joint and tissue damage. Extensive destruction of joints and large tophi can lead to deformities and loss of use of the hands and feet.

Dr. Gary Crump:

As Ed mentioned, the way KRYSTEXXA works to remove uric acid buildup is different from other medications. KRYSTEXXA breaks down uric acid, the source of uric acid crystals, into a substance called allantoin which your body can get rid of easily through your urine.

Ed:

KRYSTEXXA worked for me by tackling the source of my gout symptoms. Now I feel like I'm in control of my gout. I have fewer tophi, less deformity and less pain. My advice to someone considering KRYSTEXXA would be to understand that it is a commitment to your health and potentially a viable way to manage your gout symptoms.

Ed:

Let me tell you what I can do. I can tie my shoes and I got my wedding band on for the first time in eight years.

Narrator:

Indication and important safety information.

Narrator:

Use: KRYSTEXXA (pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

Narrator:

Important safety information: What is the most important information I should know about KRYSTEXXA (pegloticase)? Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within two hours of the infusion. KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA. Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA. Wheezing, shortness of breath, cough, chest tightness, chest pain or trouble breathing, dizziness, fainting, fast or weak heartbeat, or feeling nervous. Reddening of the face, itching, hives, rash or feeling warm, swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing.

Narrator:

Who should not receive KRYSTEXXA? Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase, (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA. KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout. Before you receive KRYSTEXXA tell your doctor if you know you have G6PD deficiency, ever had any heart problems or high blood pressure, are pregnant or planning to become pregnant, it is not known if KRYSTEXXA will harm your unborn baby, are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk. Tell your doctor about all the medicines you take.

Narrator:

Do not take any other uric acid lowering drug such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA. Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

Narrator:

What are the possible side effects of KRYSTEXXA? Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting. This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away. Please see the medication guide and prescribing information for more information. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at -800-FDA-1088.

KRYSTEXXA IS UNIQUE

Only KRYSTEXXA lowers your uric acid level enough in just 24 hours to start dissolving gout buildup and tophi.

See how KRYSTEXXA works

KRYSTEXXA IS SHORT TERM

Unlike medicines you take daily for life, you’ll go for a KRYSTEXXA treatment every two weeks for about 6 months.

View treatment process

IMPORTANT SAFETY INFORMATION

Intended for U.S residents only.

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please see the Medication Guide and Prescribing Information for more information. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.

IMPORTANT SAFETY INFORMATION

Intended for U.S residents only.

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please see the Medication Guide and Prescribing Information for more information. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.