KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments. Read More
KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments. Read More
Once you and your doctor decide KRYSTEXXA is right for you, you can enroll in Amgen By Your Side, a personalized support program. A PAL, patient access liaison, is a dedicated support partner who, while they don't give medical advice, can help investigate, explain, and educate on each step of the treatment experience.
Want to hear from someone who’s been where you are? KRYSTEXXA peer mentors are volunteers who’ve been treated with KRYSTEXXA and are happy to share their personal experiences, answer your questions, and offer support and encouragement.
Supporting someone with uncontrolled gout can be challenging—but you don’t have to do it alone. Our caregiver resources offer helpful information and encouragement to help you care for your loved one and yourself. Learn how to navigate treatment together and be an informed part of the care team.
Read transcript
Catherine
My name is Catherine, and I've been living with uncontrolled gout, and I’ve became a Peer Mentor where I can share my story with other people.
I started using a cane because my walk became unsteady. I had a hard time writing, gripping things, standing.
When my rheumatologist diagnosed me with uncontrolled gout. I'd never heard of it before.
He said you have uncontrolled gout because the medication I had prescribed you is not effective. Once I was prescribed KRYSTEXXA, I realized there was hope for me. The Peer Mentor Program is a way to communicate patient-to-patient: just everyday people that need help with uncontrolled gout.
Peer Mentors are available for patients before they start KRYSTEXXA, and they can also contact Peer Mentors after any appointment that they have.
They may have questions and want more information and peace of mind.
I've spoke to quite a few people across the United States and different stages of uncontrolled gout. But they all had the same concern: Will KRYSTEXXA help me? The more I talked about having uncontrolled gout, the more I wanted to help other people and to share my story
I had a woman contact me...her doctor didn't have a lot of time to spend with her. She couldn't understand the vocabulary words, the symptoms...and left the doctor's office with more questions. She told me she was about ready to give up. By the end of the conversation, she had hope that KRYSTEXXA was going to help her.
It helps talking to a Peer Mentor because they're going through the same thing you are. Most of it's sadness and confusion, and I answer any questions that they have and give them some hope. That’s how I humanize KRYSTEXXA: I put a voice with it.
How a patient can access the Peer Mentor Program, you can go on the website of KRYSTEXXA, and they will put you in contact with the person and you can get your questions answered.
I hope that our Peer Mentor Program expands the knowledge that they have somebody that can listen to them and explain in day-to-day language where there's some hope and help for them with their gout.
KRYSTEXXA Peer Mentors volunteer to:
Learn more about KRYSTEXXA Peer Mentors and how the program works
Khash:
When I was a young adult, I started noticing some of the characteristics of what later on became gout. Well, as time progressed, I felt like my gout was becoming more and more out of control. I get a phone call from my doctor, and he calls me to discuss gout with me. And I'm like, "Great, I've been dealing with this 25-years-plus."
Khash:
... and said, “Listen, we have this drug to help combat your gout. Are you open to it?" I said, "Yes." He was like, "We'll have a patient access liaison get in contact with you to discuss it further with you."
Lindsey:
Once you have the pre-medications in your system, the nurse is going to mix the KRYSTEXXA into an IV fluids bag. She's going to hang that up above your chair, start an IV, and the medication is going to infuse over 2 hours.
Khash:
My Patient Access Liaison, Lindsey, really took the time to explain it all to me.
Lindsey:
But after you get this first dose of KRYSTEXXA, in 2 weeks or 2 days before the next dose of KRYSTEXXA, you're going to go to the lab, you're going to get your blood drawn, and they're going to measure your serum uric acid level. Okay?
Khash:
She went over that KRYSTEXXA was IV therapy. “Initially, while we're combating it in your body, if you see any tophi, if you see anything, know that it's like a glacier. If you notice tophi on your skin, underneath it is 10 years of buildup to lead to that point. Initially, as we're attacking that, it's going to cause more flareups, more inflammation.” I'm like, "That's fine," because I've been dealing with that all these years. But I know that it's because it's a response to us dealing with the problem and getting uric acid and gout and the tophi out of my body. I'm 100% for it.
Khash:
It's a big commitment on my time, but given the severity of it and dealing with what I've had to deal with for 25 years or so, that seems small in comparison. Tomorrow's going to be my first IV therapy, so I'm looking forward to that. And it makes me look forward to the next 30, 40 years without having to deal with the same issues.
Lindsey:
You're going to have a whole team of professional nurses there to be watching you and monitoring you to make sure that you're safe.
Khash:
Excellent.
Lindsey:
Okay?
Narrator:
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about KRYSTEXXA?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.
KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.
Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:
Who should not receive KRYSTEXXA?
Do not receive KRYSTEXXA if
you:
What should I tell my doctor before receiving treatment with
KRYSTEXXA?
Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions,
including if you:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.
KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.
Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.
Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.
What are the possible side effects of KRYSTEXXA?
In KRYSTEXXA
clinical
trials:
The most common side effects of KRYSTEXXA when given together with methotrexate were gout flares, joint pain, coronavirus disease 2019 (COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA were gout flares,
allergic
reactions (including infusion reactions). See “What is the most important information I should know about
KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain, coronavirus disease 2019 (COVID-19),
and vomiting.
This is not a complete list of all possible side effects. Call your doctor for medical
advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.
For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.
USE
KRYSTEXXA® (pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).
A PAL can help you by
What is the most important information I should know about KRYSTEXXA® (pegloticase)?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.
KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.
Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:
Who should not receive KRYSTEXXA?
Do not receive KRYSTEXXA if you:
What should I tell my doctor before receiving treatment with KRYSTEXXA?
Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if you:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.
KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.
Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.
Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.
What are the possible side effects of KRYSTEXXA?
In KRYSTEXXA clinical trials:
The most common side effects of
KRYSTEXXA
when given together with methotrexate were gout flares, joint pain,
coronavirus disease 2019
(COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA
were gout
flares, allergic reactions (including infusion reactions). See “What is the most
important information I
should know about KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain,
coronavirus disease
2019 (COVID-19), and vomiting.
This is not a complete list of all possible side
effects. Call your
doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.
For additional Important Safety Information, please see the Full Prescribing Information, including Boxed Warning and Medication Guide and discuss with your doctor.
KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).
What is the most important information I should know about KRYSTEXXA® (pegloticase)?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.
