Release your everyday from gout

IF YOU HAVE MORE THAN ONE FLARE A YEAR, IT MAY BE TIME TO STEP UP YOUR GOUT TREATMENT

Recurrent gout flares may be your body’s way of telling you that oral medicines aren’t doing enough to lower your uric acid level and prevent the harmful effects of out-of-control chronic gout. KRYSTEXXA (kris-TEX-uh)
has been helping gout patients for nearly 10 years. Studies show that one IV treatment every other week for about 6 months is all you may need to take control.

WATCH JEN’S STORY

“I was at my complete breaking point.”

Read transcript

Narrator:

KRYSTEXXA (pegloticase) is a prescription medicine for adults who have tried other gout medicines and still have high uric acid and gout symptoms. KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout. Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within two hours of the infusion. Please listen to the important safety information in this video.

Jen:

The gout pain was severe, it is unlike anything else I'd ever experienced and it's literally like a band is just wrapped around your entire foot and is just tightening and tightening and tightening and it feels like it's bone crushing. This pain impacted my life because just moving around is intense pain and you can't do anything. When nothing was working, I was really thinking, "This is my life, we know what it is and I've been given medication for it and it's not working so what else is there to do at that point? I was terrified. I can't live like this." I was kind of like, "Okay, I'll go see a new doctor and he's a gout specialist, that's great. Maybe he can tell me a little bit more." He did mention KRYSTEXXA. This is an infusion drug and it's a big time commitment.

Narrator:

When trying to manage chronic gout, a uric acid level of less than six milligrams per deciliter is considered the target range. In clinical trials, 42% of patients receiving KRYSTEXXA kept their uric acid level below six milligrams per deciliter for at least six months.

Jen:

When I started KRYSTEXXA, I was in the tens, my uric acid level, and when I was on KRYSTEXXA, I was at zero. It went completely down to zero for my entire KRYSTEXXA treatment and then it slowly built back up to normal from there. For me, I was at my complete breaking point when I finally said yes to KRYSTEXXA, but I hope that people don't get there because they don't need that to get there. KRYSTEXXA had such a positive impact on my life. I want that for other people.

Narrator:

Indication and important safety information. Use: KRYSTEXXA (pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments. Important safety information: What is the most important information I should know about KRYSTEXXA (pegloticase)? Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within two hours of the infusion. KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during, and after your treatment with KRYSTEXXA.

Narrator:

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA: Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing. Dizziness, fainting, fast or weak heartbeat, or feeling nervous. Reddening of the face, itching, hives, rash, or feeling warm. Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing.

Narrator:

Who should not receive KRYSTEXXA? Do not receive KRYSTEXXA if you have a rare blood problem called glucose -6 phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA. KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout. Before you receive KRYSTEXXA, tell your doctor if you know you have G6PD deficiency, ever had any heart problems or high blood pressure, are pregnant or planning to become pregnant, it is not known if KRYSTEXXA will harm your unborn baby, are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk.

Narrator:

Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug such as allopurinol or febuxostat (Uloric®) while taking KRYSTEXXA. Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

Narrator:

What are the possible side effects of KRYSTEXXA? Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare ups, or attacks, allergic reactions, nausea, bruising, sore, throat, constipation, chest pain, and vomiting. This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away. Please see the medication guide and prescribing information for more information. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call the FDA at 1-800-FDA-1088. 


GOUT MYTH

IMPORTANT SAFETY INFORMATION

Intended for U.S residents only.

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please see the Medication Guide and Prescribing Information for more information. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.

IMPORTANT SAFETY INFORMATION

Intended for U.S residents only.

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please see the Medication Guide and Prescribing Information for more information. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.