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KRYSTEXXA has a different way of lowering uric acid levels, which is the key to stopping gout flares. In about 6 months, it can remove years of uric acid crystal buildup from your joints.

ORAL GOUT MEDICINES DON’T:

  • CONVERT URIC ACID: KRYSTEXXA is the only gout treatment that changes uric acid into a water-soluble substance called allantoin that your body easily gets rid of through urine.
  • SIGNIFICANTLY LOWER URIC ACID LEVEL IN 24 HOURS: After just one IV treatment, KRYSTEXXA starts to lower your uric acid level enough to begin dissolving years of uric acid crystal buildup.
  • DISSOLVE YEARS OF GOUT BUILDUP IN JUST MONTHS: It can take more than two years for oral gout medicines to dissolve even a small amount of uric acid crystal buildup. KRYSTEXXA can dissolve most of it in about 6 months.

HOW KRYSTEXXA WORKS

1

People with out-of-control chronic gout can’t get their uric acid level low enough, causing uric acid crystals to build up.

Illustrated image of gout in foot Illustrated image of gout in foot Illustrated image of gout in foot

2

Healthy kidneys can only get rid of about 10% of the uric acid they process, and oral gout medicines may not lower uric acid levels enough to dissolve uric acid crystal buildup.

Illustrated image of gout and kidney excreting uric acid Illustrated image of gout and kidney excreting uric acid Illustrated image of gout and kidney excreting uric acid

3

KRYSTEXXA is unique among gout treatments. It changes uric acid into a water-soluble substance called allantoin, which your body easily gets rid of through urine.

Illustrated image of gout and kidney excreting uric acid Illustrated image of gout and kidney excreting uric acid Illustrated image of gout and kidney excreting uric acid

4

Without all of that uric acid in your body, you can dissolve years of gout buildup and minimize the threat of gout attacks.

Illustrated representation of how gout treatment dissolves gout build up and works to minimize the threat of gout attacksIllustrated representation of how gout treatment dissolves gout build up and works to minimize the threat of gout attacksIllustrated representation of how gout treatment dissolves gout build up and works to minimize the threat of gout attacks

SOME PEOPLE NEED MORE THAN ORAL MEDICINES TO GET THEIR URIC ACID LEVEL LOW ENOUGH TO DISSOLVE GOUT BUILDUP

In order to dissolve gout buildup, your uric acid level should be in the dissolve zone (under 6 mg/dL).

A clinical study showed that approximately half of patients taking Zyloprim® (allopurinol) or Uloric® (febuxostat) were still unable to reach a uric acid level of 6 mg/dL or lower.* As long as you have gout buildup, you continue to be at risk of gout damage and flares.

ASK YOUR DOCTOR OR GOUT SPECIALIST WHAT YOUR URIC ACID LEVEL IS.

Graph showing how keeping uric acid levels low reduces gout flares and joint damage

Graph showing how keeping uric acid levels low reduces gout flares and joint damage

Graph showing how keeping uric acid levels low reduces gout flares and joint damage

Your uric acid level is the amount of uric acid in your blood measured in milligrams per deciliter (mg/dL).

More about the dissolve zone

*Source: Becker MA, et al. Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N Engl J Med. 2005.

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KRYSTEXXA stories icon KRYSTEXXA stories icon KRYSTEXXA stories icon

PROVEN RESULTS

KRYSTEXXA WAS STUDIED IN TWO 6-MONTH CLINICAL TRIALS

128 adult patients diagnosed with chronic gout received either KRYSTEXXA (8 mg dose) or a placebo every 2 weeks.

Patient results icon

42% of patients

KEPT THEIR URIC ACID LEVELS BELOW 6 mg/dL FOR 6 MONTHS OR MORE.THE REST OF THE PATIENTS WERE ABLE TO KEEP THEIR URIC ACID LEVELS BELOW THE GOAL OF 6 mg/dL FOR AN AVERAGE OF 7 WEEKS.

Tophi dissolution icon

45% of patients

HAD ONE VISIBLE LUMP (TOPHUS) COMPLETELY DISAPPEAR IN 6 MONTHS.IN THESE SAME PATIENTS, THERE WAS NO NEW TOPHI GROWTH.

Response time icon

WITHIN 24 HOURS OF THE FIRST IV TREATMENT,

THE AVERAGE URIC ACID LEVEL OF PATIENTS WHO RESPONDED TO KRYSTEXXA WAS1 mg/dL.THE LOWER YOUR URIC ACID LEVEL, THE FASTER GOUT BUILDUP DISSOLVES.

KRYSTEXXA CAN MAKE A DRAMATIC DIFFERENCE

In clinical trials, nearly half of KRYSTEXXA patients had at least one tophus completely go away after 6 months, and they didn’t experience any new tophi growth.

  • Before
  • At 3 months
  • At 6 months

Signs of uncontrolled
chronic gout

Are you missing out on life? See what out-of-control chronic gout can look like.

Learn the signs

The KRYSTEXXA
treatment process

Unlike medicines you take long-term, KRYSTEXXA is given every 2 weeks for about 6 months.

View each step

IMPORTANT SAFETY INFORMATION

Intended for U.S residents only.

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please see the Medication Guide and Prescribing Information for more information. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.

IMPORTANT SAFETY INFORMATION

Intended for U.S residents only.

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please see the Medication Guide and Prescribing Information for more information. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.