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Get into the Uric Acid Crystal Dissolve Zone

In order to dissolve the uric acid crystal buildup that causes gout to become out of control, your uric acid level needs to be in the Uric Acid Crystal Dissolve Zone. The goal of KRYSTEXXA is to get you into the Uric Acid Crystal Dissolve Zone and keep you there until your gout buildup is gone.

Do you know your uric acid level?

Select your level.

Knowing your uric acid level is important for diagnosing out-of-control gout. Find a gout specialist who can tell you your uric acid level with a simple blood test.

Click on each level to learn more about the dissolve zone.

Gout buildup zone

If your uric acid level is above 6.8 mg/dL, uric acid crystals can build up in your joints and tissues (including organs), increasing your risk of permanent joint and bone damage. Plus, the frequency of gout flares may be increasing. Even if you take gout medicine every day, your uric acid level may still be too high. Find a specialist who can help you take control of gout or get a discussion guide with questions to ask your gout specialist.

Gout buildup zone

When your uric acid level is above 6 mg/dL, gout flares may occur as uric acid crystals slowly continue to build up, increasing your risk of permanent joint and bone damage. Even if you take gout medicine every day, your uric acid level may still be too high to control gout. Find a doctor who can help you take control of gout or download a discussion guide with questions for your rheumatologist or nephrologist.

Gout dissolve zone

When your uric acid level is 5.9 mg/dL and below, uric acid crystals can begin to melt away, slowly dissolving visible and nonvisible tophi. You also may be experiencing fewer gout flares. KRYSTEXXA gets most people into the dissolve zone within 24 hours of the first treatment. If you are in the dissolve zone and still having gout flares, use our doctor discussion guide to find out if KRYSTEXXA is right for you.

Gout dissolve zone

You’re well into the dissolve zone, which starts at 5.9 mg/dL. As you get further into the dissolve zone, you have a greater potential of resolving tophi, faster dissolving of uric acid crystals, and less risk of uric acid crystals building up and causing gout symptoms. After Jen’s first KRYSTEXXA treatment, her uric acid level went down to 0. Hear her story.

KRYSTEXXA can dissolve visible and nonvisible buildup

Image representing uric acid crystals dissolving Image representing uric acid crystals dissolving Image representing uric acid crystals dissolving
  • Uric acid crystals build up over time in your body, similarly to the way snow collects on the sidewalk
  • KRYSTEXXA is an enzyme that helps uric acid crystals dissolve, like the way salt melts snow
  • Dissolved uric acid crystals leave your body through urine, just as melted snow flows down a drain

USE AND IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat, or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency, or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid–lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please see the Medication Guide and Prescribing Information for more information. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.

USE AND IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat, or feeling nervous
  • Reddening of the face, itching, hives, rash, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you have a rare blood problem called glucose 6-phosphate dehydrogenase (G6PD) deficiency, or favism. Your doctor should test you for G6PD before you start KRYSTEXXA.

KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.

Before you receive KRYSTEXXA, tell your doctor if you:

  • Know you have G6PD deficiency
  • Ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk

Tell your doctor about all the medicines you take. Do not take any other uric acid–lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

Please review important information section above. The most common side effects in patients taking KRYSTEXXA were gout flare-ups or attacks, allergic reactions, nausea, bruising, sore throat, constipation, chest pain, and vomiting.

This is not a complete list of all possible side effects. Tell your doctor or treatment team if you have any side effect that bothers you or that does not go away.

Please see the Medication Guide and Prescribing Information for more information. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call the FDA at 1-800-FDA-1088.