Choose the best gout IV treatment setting for you

KRYSTEXXA is a biologic treatment, which means it's made from a living source. Biologics are at the forefront of medical advances and can treat the causes of diseases rather than the symptoms. Some biologics are delivered directly into the bloodstream via an intravenous (IV) infusion that you can receive in a variety of settings.

Site of care options

Stethoscope iconStethoscope iconStethoscope icon

Doctor’s office

Your doctor may be able to give you KRYSTEXXA right in his or her office.

Gout infusion iconGout infusion iconGout infusion icon

IV treatment center

As more IV treatments become available, so do more choices of standalone IV treatment centers.

Hospital iconHospital iconHospital icon

Hospital

Hospitals with outpatient IV treatment centers may be a convenient option.

Compare your options

Wherever you get KRYSTEXXA, a trained healthcare professional will administer your treatment and monitor you through the duration—usually about 2 hours—for signs of an infusion reaction or other side effects that they can treat on the spot. To help manage out-of-control gout, it’s important to receive KRYSTEXXA every 2 weeks for 6 to 12 months* or for as long as your doctor recommends.

*Best results were seen after 6 to 12 months of treatment. Optimal treatment duration has not been established.

Site of care Benefits at a glance
Stethoscope icon Doctor’s office
  • Familiar staff and environment
  • You know if the office accepts your insurance
  • No need to wait for your records to transfer
Gout infusion icon IV treatment
center
  • Specialized in IV infusions
  • Growing number of locations
  • Flexible hours and private suites
Hospital icon Hospital
  • May offer outpatient infusions
  • Centrally located
  • Many specialties under 1 roof
Site of care
Doctor’s office
Benefits at a glance
  • Familiar staff and environment
  • You know if the office accepts your insurance
  • No need to wait for your records to transfer
Site of care
IV treatment center
Benefits at a glance
  • Specialized in IV infusions
  • Growing number of locations
  • Flexible hours and private suites
Site of care
Hospital
Benefits at a glance
  • May offer outpatient infusions
  • Centrally located
  • Many specialties under 1 roof

Discuss your options with a Patient Access Liaison

If your doctor decides that KRYSTEXXA is right for you, a Patient Access Liaison (PAL) can tell you more about each site of care, check your insurance coverage, and help you identify options for IV treatment centers near you.

How to take KRYSTEXXA along with methotrexate

Your doctor may prescribe KRYSTEXXA with a medication called methotrexate to reduce the symptoms of out-of-control gout. You will also be given folic acid to help prevent some of the side effects of methotrexate. Your doctor will explain the dosing schedule.

At Month 6 of a clinical study

71% of people on KRYSTEXXA
along with methotrexate kept their
uric acid levels below 6 mg/dL

39% of people on KRYSTEXXA alone
kept their uric acid
levels below 6 mg/dL

KRYSTEXXA is approved to be given with methotrexate

Methotrexate can help KRYSTEXXA work better than it did before.

See how KRYSTEXXA with methotrexate works

Starting treatment for out-of-control
gout using KRYSTEXXA with methotrexate

Improvement is typically seen in 6 to 12 months. If you and your doctor decide methotrexate is not right for you, KRYSTEXXA is effective when taken alone.

Optimal treatment duration has not been established.

Before treatment

Treatment IconTreatment IconTreatment Icon

Your doctor will prescribe other medicine to help your body prepare for KRYSTEXXA.

You will start this other medicine 4 weeks before you start KRYSTEXXA.

The other
medicine includes

Medicine IconMedicine IconMedicine Icon

  • Daily folic acid
  • Weekly methotrexate, usually given by mouth

Starting with your first
KRYSTEXXA infusion

Infusion IconInfusion IconInfusion Icon

You will start receiving KRYSTEXXA IV treatments every 2 weeks.

You will receive corticosteroids and allergy medicine on the days of your infusions to prevent allergic reactions to KRYSTEXXA, as prescribed by your doctor.

You will continue to take folic acid every day and methotrexate once a week.

KRYSTEXXA is short-term

Unlike medicines you take daily for life, KRYSTEXXA is given every two weeks and best results were seen within 6-12 months.

Optimal treatment duration has not been
established.

Treatment timeline

Ask someone who’s been there

Talk to a patient who may have experience choosing an IV treatment location and taking KRYSTEXXA.

Request a peer mentor

USE AND IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA® (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.

USE AND IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA® (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • dizziness, fainting, fast or weak heartbeat or feeling nervous
  • reddening of the face, itching, hives, or feeling warm
  • swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you:

  • have a rare blood problem called glucose-6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor may test you for G6PD before you start KRYSTEXXA.
  • have had a serious allergic reaction to KRYSTEXXA or any of its ingredients. See the end of the Medication Guide for a complete list of ingredients in KRYSTEXXA.

What should I tell my doctor before receiving treatment with KRYSTEXXA?

Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if you:

  • ever had any heart problems or high blood pressure.
  • are pregnant or plan to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk. You and your doctor should decide if you will receive KRYSTEXXA or breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.

KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

In KRYSTEXXA clinical trials:
The most common side effects of KRYSTEXXA when given together with methotrexate were
gout flares, joint pain, coronavirus disease 2019 (COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA were gout flares, allergic reactions (including infusion reactions). See “What is the most important information I should know about KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain, coronavirus disease 2019 (COVID-19), and vomiting.
This is not a complete list of all possible side effects. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.

For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).

USE AND IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA® (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.

USE AND IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA® (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • dizziness, fainting, fast or weak heartbeat or feeling nervous
  • reddening of the face, itching, hives, or feeling warm
  • swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you:

  • have a rare blood problem called glucose-6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor may test you for G6PD before you start KRYSTEXXA.
  • have had a serious allergic reaction to KRYSTEXXA or any of its ingredients. See the end of the Medication Guide for a complete list of ingredients in KRYSTEXXA.

What should I tell my doctor before receiving treatment with KRYSTEXXA?

Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if you:

  • ever had any heart problems or high blood pressure.
  • are pregnant or plan to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk. You and your doctor should decide if you will receive KRYSTEXXA or breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.

KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

In KRYSTEXXA clinical trials:
The most common side effects of KRYSTEXXA when given together with methotrexate were
gout flares, joint pain, coronavirus disease 2019 (COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA were gout flares, allergic reactions (including infusion reactions). See “What is the most important information I should know about KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain, coronavirus disease 2019 (COVID-19), and vomiting.
This is not a complete list of all possible side effects. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.

For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).